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syn1  (Proteintech)


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    Structured Review

    Proteintech syn1
    Mechanisms of PMLpGL Treatment for Neuroinflammation-Induced Cognitive Decline. (A) TUNEL in the hippocampal region. Scale bars: 100 μm. (B) Dual IF of IBA-1 and GFAP. Scale bars: 100 μm. (C) Dual IF of PD-1 and PD-L1. Scale bars: 100 μm. (D) Western blot analysis of NF-κB, Caspase-3, and <t>SYN1</t> expression. (E) Densitometry of panel D. (n = 3), all vs. PMLpGL. (F) Schematic of the proposed mechanism. Data are presented as mean ± SD. ∗∗∗ P < 0.001. Abbreviations: IF: immunofluorescence.
    Syn1, supplied by Proteintech, used in various techniques. Bioz Stars score: 95/100, based on 76 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/syn1/product/Proteintech
    Average 95 stars, based on 76 article reviews
    syn1 - by Bioz Stars, 2026-03
    95/100 stars

    Images

    1) Product Images from "Glycyrrhizic acid-loaded biomimetic hybrid liposomes targeting inflammatory cascades and PD-1/PD-L1 pathway to reverse neuroinflammation-driven cognitive decline"

    Article Title: Glycyrrhizic acid-loaded biomimetic hybrid liposomes targeting inflammatory cascades and PD-1/PD-L1 pathway to reverse neuroinflammation-driven cognitive decline

    Journal: Materials Today Bio

    doi: 10.1016/j.mtbio.2025.102657

    Mechanisms of PMLpGL Treatment for Neuroinflammation-Induced Cognitive Decline. (A) TUNEL in the hippocampal region. Scale bars: 100 μm. (B) Dual IF of IBA-1 and GFAP. Scale bars: 100 μm. (C) Dual IF of PD-1 and PD-L1. Scale bars: 100 μm. (D) Western blot analysis of NF-κB, Caspase-3, and SYN1 expression. (E) Densitometry of panel D. (n = 3), all vs. PMLpGL. (F) Schematic of the proposed mechanism. Data are presented as mean ± SD. ∗∗∗ P < 0.001. Abbreviations: IF: immunofluorescence.
    Figure Legend Snippet: Mechanisms of PMLpGL Treatment for Neuroinflammation-Induced Cognitive Decline. (A) TUNEL in the hippocampal region. Scale bars: 100 μm. (B) Dual IF of IBA-1 and GFAP. Scale bars: 100 μm. (C) Dual IF of PD-1 and PD-L1. Scale bars: 100 μm. (D) Western blot analysis of NF-κB, Caspase-3, and SYN1 expression. (E) Densitometry of panel D. (n = 3), all vs. PMLpGL. (F) Schematic of the proposed mechanism. Data are presented as mean ± SD. ∗∗∗ P < 0.001. Abbreviations: IF: immunofluorescence.

    Techniques Used: TUNEL Assay, Western Blot, Expressing, Immunofluorescence



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    Mechanisms of PMLpGL Treatment for Neuroinflammation-Induced Cognitive Decline. (A) TUNEL in the hippocampal region. Scale bars: 100 μm. (B) Dual IF of IBA-1 and GFAP. Scale bars: 100 μm. (C) Dual IF of PD-1 and PD-L1. Scale bars: 100 μm. (D) Western blot analysis of NF-κB, Caspase-3, and <t>SYN1</t> expression. (E) Densitometry of panel D. (n = 3), all vs. PMLpGL. (F) Schematic of the proposed mechanism. Data are presented as mean ± SD. ∗∗∗ P < 0.001. Abbreviations: IF: immunofluorescence.
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    Mechanisms of PMLpGL Treatment for Neuroinflammation-Induced Cognitive Decline. (A) TUNEL in the hippocampal region. Scale bars: 100 μm. (B) Dual IF of IBA-1 and GFAP. Scale bars: 100 μm. (C) Dual IF of PD-1 and PD-L1. Scale bars: 100 μm. (D) Western blot analysis of NF-κB, Caspase-3, and <t>SYN1</t> expression. (E) Densitometry of panel D. (n = 3), all vs. PMLpGL. (F) Schematic of the proposed mechanism. Data are presented as mean ± SD. ∗∗∗ P < 0.001. Abbreviations: IF: immunofluorescence.
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    Mechanisms of PMLpGL Treatment for Neuroinflammation-Induced Cognitive Decline. (A) TUNEL in the hippocampal region. Scale bars: 100 μm. (B) Dual IF of IBA-1 and GFAP. Scale bars: 100 μm. (C) Dual IF of PD-1 and PD-L1. Scale bars: 100 μm. (D) Western blot analysis of NF-κB, Caspase-3, and <t>SYN1</t> expression. (E) Densitometry of panel D. (n = 3), all vs. PMLpGL. (F) Schematic of the proposed mechanism. Data are presented as mean ± SD. ∗∗∗ P < 0.001. Abbreviations: IF: immunofluorescence.
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    Image Search Results


    Mechanisms of PMLpGL Treatment for Neuroinflammation-Induced Cognitive Decline. (A) TUNEL in the hippocampal region. Scale bars: 100 μm. (B) Dual IF of IBA-1 and GFAP. Scale bars: 100 μm. (C) Dual IF of PD-1 and PD-L1. Scale bars: 100 μm. (D) Western blot analysis of NF-κB, Caspase-3, and SYN1 expression. (E) Densitometry of panel D. (n = 3), all vs. PMLpGL. (F) Schematic of the proposed mechanism. Data are presented as mean ± SD. ∗∗∗ P < 0.001. Abbreviations: IF: immunofluorescence.

    Journal: Materials Today Bio

    Article Title: Glycyrrhizic acid-loaded biomimetic hybrid liposomes targeting inflammatory cascades and PD-1/PD-L1 pathway to reverse neuroinflammation-driven cognitive decline

    doi: 10.1016/j.mtbio.2025.102657

    Figure Lengend Snippet: Mechanisms of PMLpGL Treatment for Neuroinflammation-Induced Cognitive Decline. (A) TUNEL in the hippocampal region. Scale bars: 100 μm. (B) Dual IF of IBA-1 and GFAP. Scale bars: 100 μm. (C) Dual IF of PD-1 and PD-L1. Scale bars: 100 μm. (D) Western blot analysis of NF-κB, Caspase-3, and SYN1 expression. (E) Densitometry of panel D. (n = 3), all vs. PMLpGL. (F) Schematic of the proposed mechanism. Data are presented as mean ± SD. ∗∗∗ P < 0.001. Abbreviations: IF: immunofluorescence.

    Article Snippet: Antibodies for immunofluorescence and Western blot included Ionized calcium-binding adapter molecule 1 (IBA1) Polyclonal Antibody, PD-1 Monoclonal Antibody, PD-L1 Monoclonal Antibody, Synapsin I (SYN1)-specific Polyclonal Antibody, Nuclear factor kappa-light-chain-enhancer of activated B cells, p65 subunit (NF-κB p65) Polyclonal Antibody, Caspase-3/P17/P19 Polyclonal Antibody, Glial fibrillary acidic protein (GFAP) Polyclonal Antibody, Anti-beta Actin (β actin) Rabbit pAb, horseradish peroxidase (HRP)-conjugated Affinipure Goat Anti-Rabbit IgG (H + L), luorescein isothiocyanate (FITC)-conjugated Affinipure Goat Anti-Rabbit IgG (H + L), and R-phycoerythrin (PE)–conjugated Goat Anti-Rabbit IgG (H + L), and all were from Proteintech (Wuhan, China).

    Techniques: TUNEL Assay, Western Blot, Expressing, Immunofluorescence